Intracellular NAMPT–NAD+–SIRT1 cascade improves post-ischaemic vascular repair by modulating Notch signalling in endothelial progenitors

AimsIntracellular nicotinamide phosphoribosyltransferase (NAMPT) is the rate-limiting enzyme for nicotinamide adenine dinucleotide (NAD+) biosynthesis. This study investigated the role of NAMPT-mediated NAD+ signalling in post-ischaemic vascular repair.