细胞内
感光细胞
黄斑变性
色素性视网膜炎
视网膜变性
程序性细胞死亡
视网膜
化学
生物物理学
细胞生物学
材料科学
细胞凋亡
纳米颗粒
活性氧
纳米技术
视网膜
医学
生物
生物化学
眼科
神经科学
作者
Junping Chen,Swanand Patil,Sudipta Seal,James F. McGinnis
标识
DOI:10.1038/nnano.2006.91
摘要
Photoreceptor cells are incessantly bombarded with photons of light, which, along with the cells' high rate of oxygen metabolism, continuously exposes them to elevated levels of toxic reactive oxygen intermediates (ROIs). Vacancy-engineered mixed-valence-state cerium oxide nanoparticles (nanoceria particles) scavenge ROIs. Our data show that nanoceria particles prevent increases in the intracellular concentrations of ROIs in primary cell cultures of rat retina and, in vivo, prevent loss of vision due to light-induced degeneration of photoreceptor cells. These data indicate that the nanoceria particles may be effective in inhibiting the progression of ROI-induced cell death, which is thought to be involved in macular degeneration, retinitis pigmentosa and other blinding diseases, as well as the ROI-induced death of other cell types in diabetes, Alzheimer's disease, atherosclerosis, stroke and so on. The use of nanoceria particles as a direct therapy for multiple diseases represents a novel strategy and suggests that they may represent a unique platform technology.
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