脊髓损伤
再生(生物学)
脊髓
神经营养因子
脑源性神经营养因子
细胞外基质
中枢神经系统
医学
神经科学
麻醉
细胞生物学
内科学
生物
受体
作者
Wei Liang,Qianqian Han,Wei Jin,Zhifeng Xiao,Jin Huang,Hongbin Ni,Bing Chen,Jie Kong,Jun Wu,Jianwu Dai
出处
期刊:Biomaterials
[Elsevier]
日期:2010-11-01
卷期号:31 (33): 8634-8641
被引量:63
标识
DOI:10.1016/j.biomaterials.2010.07.084
摘要
Spinal cord crushed injury is clinically common. Promoting targeted neural regeneration at the crushed site of spinal cord could be important for the repair. It has been demonstrated in our previous work that native human BDNF fused with a collagen-binding domain (CBD-BDNF) can bind to collagen specifically to exert the neurotrophic effect on promoting axonal regeneration. After injury, collagen is highly accumulated at the injury site. We thus speculate that CBD-BDNF will bind to the extracellular matrix collagen and concentrate at the injury site to improve the therapy. Using the rat spinal cord crushed injury model, we have found that CBD-BDNF by one-time intrathecally injection could be retained and concentrated at the injury site for a longer time than native BDNF without collagen-binding domain. CBD-BDNF could promote better neural regeneration and locomotion recovery.
科研通智能强力驱动
Strongly Powered by AbleSci AI