化学
非对映体
衍生化
对映体
色谱法
氨基酸
手性(物理)
硫脲
手性衍生剂
高效液相色谱法
有机化学
对映选择合成
肽
共价键
分辨率(逻辑)
手性柱色谱法
组合化学
分析物
洗脱
对映体过量
检出限
手性固定相
试剂
催化作用
物理
量子力学
生物化学
手征对称破缺
Nambu–Jona Lasinio模型
夸克
作者
István Ilisz,Róbert Berkecz,Antal Péter
标识
DOI:10.1016/j.jpba.2007.12.013
摘要
The past 20 years has seen an explosive growth in the field of chirality, as illustrated by the rapid progress in the various facets of this intriguing field. The impetus for advances in chiral separation has been highest in the past decade and this still continues to be an area of high focus. This paper reviews indirect separation approaches, i.e. derivatization reactions aimed at creating the basis for the chromatographic resolution of biologically and pharmaceutically important enantiomers, with emphasis on the literature published in the last 12 years. The main aspects of the chiral derivatization of amino acids are discussed, i.e. derivatization on the amino group, transforming the molecules into covalently bonded diastereomeric derivatives through the use of homochiral derivatizing agents. The diastereomers formed (amides, urethanes, urea, thiourea derivatives, etc.) can be separated on achiral stationary phases. The applications are considered, and in some cases different derivatizing agents for the resolution of complex mixtures of proteinogenic d,l-amino acids, non-proteinogenic amino acids and peptides/amino acids from peptide syntheses or microorganisms are compared.
科研通智能强力驱动
Strongly Powered by AbleSci AI