孕酮受体
基因亚型
受体
生物
功能(生物学)
内分泌学
体内
内科学
基因
细胞生物学
遗传学
雌激素受体
医学
癌症
乳腺癌
作者
Biserka Mulac‐Jeričević,Robert A. Mullinax,Francesco J. DeMayo,John P. Lydon,Orla M. Conneely
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2000-09-08
卷期号:289 (5485): 1751-1754
被引量:644
标识
DOI:10.1126/science.289.5485.1751
摘要
Progesterone regulates reproductive function through two intracellular receptors, progesterone receptor-A (PR-A) and progesterone receptor-B (PR-B), that arise from a single gene and function as transcriptional regulators of progesterone-responsive genes. Although in vitro studies show that PR isoforms can display different transcriptional regulatory activities, their physiological significance is unknown. By selective ablation of PR-A in mice, we show that the PR-B isoform modulates a subset of reproductive functions of progesterone by regulation of a subset of progesterone-responsive target genes. Thus, PR-A and PR-B are functionally distinct mediators of progesterone action in vivo and should provide suitable targets for generation of tissue-selective progestins.
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