类黄酮
化学
药理学
体外
传统医学
单核细胞
细胞毒性
牡荆
化学发光
趋化性
IC50型
生物化学
生物
免疫学
医学
抗氧化剂
色谱法
受体
作者
M. Ahmed Mesaik,- Azizuddin,Shahnaz Murad,Khalid Mohammed Khan,Rasool Bakhsh Tareen,Aqeel Ahmed,_ Atta-ur-Rahman,M. Iqbal Choudhary
摘要
Casticin (1), a flavonoid isolated from the aerial parts of Vitex agnus-castus, was found to be a potent immunomodulatory and cytotoxic compound. The activity was tested in vitro for chemiluminescence, chemotaxis, T-cell proliferation and cytotoxicity. Casticin (1) exhibited a significant inhibitory effect on monocyte oxidative burst in a dose dependent manner. It was found to have a significant suppressive effect on the chemotaxic action at higher concentrations on fMLP (10−8 m) stimulated neutrophils. It also showed a potent suppressive effect on PHA stimulated T-cell (PMBC). Copyright © 2009 John Wiley & Sons, Ltd.
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