化学
催化作用
亲核细胞
路易斯酸
甲酰胺
磷化氢
亲核取代
有机化学
氧化膦
基础(拓扑)
药物化学
组合化学
数学
数学分析
作者
Peter H. Huy,Tanja Hauch,Isabel Filbrich
出处
期刊:Synlett
[Georg Thieme Verlag KG]
日期:2016-10-18
卷期号:27 (19): 2631-2636
被引量:33
标识
DOI:10.1055/s-0036-1588633
摘要
Nucleophilic substitutions (SN) at sp3-hybridized carbon centers are one of the most fundamental type of transformation in organic synthesis. Taking the importance of bimolecular SN reactions into account, catalytic variants must be considered as underdeveloped. This review highlights the most recent progress in the emerging field of Lewis base catalyzed SN-type transformations that are mediated by simple acid chlorides and anhydrides. 1 Introduction 2 Phosphine Oxide and Cyclopropenone Catalysis 3 Formamide Catalysis 4 Other Catalytic Systems 5 Conclusion
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