RECIST 1.1, irRECIST 1.1, and mRECIST: How to Do

This review aims to give a brief update how to do RECIST 1.1, irRECIST 1.1, and mRECIST. The revised Response Evaluation Criteria in Solid Tumors (RECIST 1.1) are currently representing the most commonly used and validated response criteria for objective treatment monitoring of conventional chemotherapies in solid tumors. However, with the introduction of novel molecular drugs and local tumor therapies, such as selective transarterial chemoembolization (TACE) at hepatocellular carcinomas (HCC), limitations of the conventional RECIST 1.1 became obvious due to specific response pattern, which are not reflected. Thus, for a comprehensive evaluation of immunotherapeutic agents new immune-related RECIST (irRECIST 1.1) and of selective HCC treatment modified RECIST (mRECIST) criteria have been published. RECIST 1.1 presents the most used response criteria for conventional chemotherapies in solid tumors. For specific evaluation of immunotherapeutic agents irRECIST 1.1 and of selective HCC treatment mRECIST have been established.