纳米发生器
材料科学
神经调节
迷走神经电刺激
迷走神经
压电
能量收集
生物医学工程
纳米技术
刺激
功率(物理)
医学
复合材料
内科学
量子力学
物理
作者
Yuanzheng Zhang,Liping Zhou,Xiangyang Gao,Chengzhe Liu,Huaqiang Chen,Haiwu Zheng,Jinzheng Gui,Chengliang Sun,Lilei Yu,Shishang Guo
出处
期刊:Nano Energy
[Elsevier]
日期:2021-11-01
卷期号:89: 106319-106319
被引量:34
标识
DOI:10.1016/j.nanoen.2021.106319
摘要
Vagus nerve stimulation (VNS) has emerged as a promising device-based neuromodulatory therapy that is expected to replace part of the traditional drugs, to treat various neuropsychiatric, inflammatory-immune, and cardiovascular diseases. Thus VNS device modification to enhance function features and improve operation safety is of great significance for expanding clinical application. Herein, we design a self-powered VNS device based on piezoelectric nanogenerator (PENG) that is battery-free and can successfully harvest biomechanical energy from the carotid artery pulsation to stimulate the vagus nerve. Among them, the flexible PENGs are prepared through electrospinning and layer-by-layer assembly using poly(vinylidene fluoride-co-trifluoroethylene) [P(VDF-TrFE)]/BaTiO3 (BTO). Multi-unit PENG shows outstanding output performance due to more generation units and ameliorated stress distribution. The maximum instantaneous power density is superior to most devices prepared with the same raw materials. COMSOL simulation results prove the notable amelioration in stress distribution inside multi-unit PENG. When the self-powered VNS device releases electrical stimulation to the vagus nerve, the heart rate of the four canines decreased significantly. This work not only broadens the application scope of the flexible PENG for energy harvesting, but also puts forward the novel concept of PENG-based self-powered vagal neuromodulation system.
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