骨整合
材料科学
涂层
复合数
纳米复合材料
壳聚糖
电化学
抗菌活性
钛
核化学
化学工程
纳米技术
化学
植入
电极
复合材料
冶金
细菌
医学
物理化学
外科
工程类
生物
遗传学
作者
Jianghong Luo,Bakri Mamat,Zhihao Yue,Naiyin Zhang,Xiaojun Xu,Yunling Li,Zhi Su,Chuang Ma,Fazhi Zang,Yingbo Wang
标识
DOI:10.1016/j.colcom.2021.100435
摘要
The Hydroxyapatite (HA) coating on the surface of titanium (Ti) with good bioactivity for osseointegration ability, however, the lack of antibacterial properties. In this study, the pulse electrochemical method was used to oxidize and polymerize pyrrole (Py) into polypyrrole (PPy) in situ, and PPy was used as the regulator of HA nanoparticles (HA-NPs) and metal particles to construct uniform [email protected]/ZnO-Cu, [email protected]/ZnO-Ag, [email protected]/Ag-Cu, and [email protected]/ZnO-Ag-Cu nanocomposite coatings on the Ti substrate. The antibacterial rates of four groups of composite coatings against Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli) were all 100%. The [email protected]/ZnO-Ag composite coating could promote the growth and proliferation of Vascular Endothelial Cells (VECs) and Bone Marrow Mesenchymal Stem Cells (BMSCs). Therefore, the [email protected]/ZnO-Ag composite coating has the best osteoinductive ability among all the groups, excellent antibacterial property, angiogenic and osteogenic capability, which can be used as an ideal implant coating.
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