作者
Raheel Iftikhar,Parvez Ahmad,Régis de Latour,Carlo Dufour,Antonio M. Risitano,Naeem Chaudhri,Ali Bazarbachi,Josu de la Fuente,Britta Höchsmann,Syed Osman Ahmed,Usama Gergis,Alaa Elhaddad,Constantijn J.M. Halkes,Bassim Albeirouti,Sultan Alotaibi,Austin Kulasekararaj,Hazzaa Alzahrani,Tarek Ben Othman,Simone Cesaro,Ali Al-Ahmari,Rawad Rihani,Salem Alshemmari,Amir Ali Hamidieh,Mohamed‐Amine Bekadja,Jakob Passweg,Murtadha Al-Khabori,Walid Rasheed,Andrea Bacigalupo,Qamar-Un-Nisa Chaudhry,Per Ljungman,Judith Marsh,Riad El Fakih,Mahmoud Aljurf,Eastern Mediterranean Blood,Marrow Transplantation
摘要
Aplastic anemia is a relatively rare but potentially fatal disorder, with a reported higher incidence in developing countries in comparison to the West. There are significant variations in epidemiological as well as etiological factors of bone marrow failure syndromes in the developing countries in comparison to the developed world. Furthermore, the management of bone marrow failure syndromes in resource constraint settings has significant challenges including delayed diagnosis and referral, limited accessibility to healthcare facilities, treatment modalities as well as limitations related to patients who require allogeneic stem cell transplantation. Here we will provide a review of the available evidence related to specific issues of aplastic anemia in the developing countries and we summarize suggested recommendations from the Eastern Mediterranean blood and bone marrow transplantation (EMBMT) group and the severe aplastic anemia working party of the European Society of blood and marrow transplantation (SAAWP of EBMT) related to the diagnosis and therapeutic options in countries with restricted resources.