Mechanisms of Sinomenine Nanoparticles in the Treatment of Breast Cancer Based on Network Pharmacology

Abstract This article mainly discusses the mechanism of SINOMENINE nanoparticles in the treatment of breast cancer by using the network pharmacology method. TCMSP and Swiss Target Prediction databases were searched for the target of SINOMENINE. The “breast cancer” target was searched through the GeneCards database. The common targets of both SINOMENINE and breast cancer were considered as the targets of SINOMENINE for treating breast cancer. The software Cytoscape 3.7.1 was used for topological analysis and visualization. The DAVID databases were used for GO enrichment analysis. A total of 57 key targets for the treatment of breast cancer were obtained, of which AKT1, MTOR, EGFR, NOS3, MAPK8, MMP9, etc. The results of pathway enrichment and functional annotation show that SINOMENINE mainly involves protein phosphorylation and positive regulation of nitric oxidebiosynthetic process by regulating Sphingolipid signaling pathway, Pathways in cancer, Measles, Smallcell lung cancer, Focal adhesion, and Insulin resistance. There are 10 major biological processes, including protein phosphorylation, signal transduction, negative regulation of apoptotic process, and protein autophosphorylation. This study not only initially revealed potential molecular mechanism of SINOMENINE, but also provided a reference for the in-depth development of SINOMENINE nanoparticles for the treatment of breast cancer.