Receptor de rianodina, fuga de calcio y arritmias

The participation of the ionic Ca 2+ release channel/ryanodine receptor in cardiac excitation-contraction coupling is well known since the late '80s, when various seminal papers communicated its purification for the first time and its identity with the ''foot'' structures located at the terminal cisternae of the sarcoplasmic reticulum.In addition to its main role as the Ca 2+ channel responsible for the transient Ca 2+ increase that activates the contractile machinery of the cardiomyocytes, the ryanodine receptor releases Ca 2+ during the relaxation phase of the cardiac cycle, giving rise to a diastolic Ca 2+ leak.In normal physiological conditions,