斯特罗比林
嘧啶
铅化合物
化学
生物测定
杀螨剂
立体化学
组合化学
有机化学
体外
生物
生物化学
植物
杀菌剂
阿米西达
遗传学
作者
Baoshan Chai,Changling Liu,Huichao Li,Xiao-Min He,Yanmei Luo,G. Huang,Hong Zhang,Junbiao Chang
摘要
Abstract BACKGROUND: The intermediate derivatisation method based on bioisosteric replacement led to the discovery of the lead strobilurin compound 5a. To produce new strobilurin analogues with improved activity, a series of substituted pyrimidines were synthesised and bioassayed. RESULTS: The compounds were identified by 1 H NMR, IR, MS and elemental analysis. The highly active compound 5g was studied by X‐ray diffraction. Preliminary bioassays demonstrated that some of the title compounds exhibited excellent acaricidal activity against Tetranychus cinnabarinus (Boisd.) at 10 mg L −1 . The relationship between structure and acaricidal activity is reported. CONCLUSION: The present work demonstrates that strobilurin derivatives containing pyrimidine moieties can be used as possible lead compounds for developing novel acaricides. Copyright © 2010 Society of Chemical Industry
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