抗dsDNA抗体
抗体
狼疮性肾炎
自身抗体
医学
免疫学
发病机制
纳米医学
DNA
化学
疾病
病理
纳米技术
材料科学
生物化学
纳米颗粒
作者
Ting Liu,Xi Zhang,Lizhen He,Zehang Zhang,Yuhan Sun,Jiarong Feng,Zhiming Lin,Tianfeng Chen
标识
DOI:10.1016/j.cej.2021.133095
摘要
Systemic lupus erythematosus (SLE) with increasing morbidity and mortality rate is characterized by multisystem damage and diverse autoantibodies production, such as anti-double stranded (ds) DNA antibodies. It is noted that anti-dsDNA antibodies are essential in the pathogenesis and progression of SLE and lupus nephritis (LN), however; anti-dsDNA antibodies could not be specifically recognized and quickly removed in clinic. Therefore, it is urgently needed to develop SLE-specific targeting agents to improve the diagnose and treatment of SLE. Herein, a selenium nanosystem (DNA-SeNPs) with surface decoration of calf thymus DNA (ctDNA) was constructed to specifically recognize and remove anti-dsDNA autoantibodies in the serums of 128 SLE patients and in the kidneys of 36 LN patients. The nanotherapeutics exhibited perfect biocompatibility and safety in patients to directly eliminate anti-dsDNA antibodies. In addition, the clearance ratio of anti-dsDNA antibodies by DNA-SeNPs was notably higher than other products widely used in clinical practice, implying that the excellent removal efficiency of this nanotherapeutics. Importantly, DNA-SeNPs not only help to visualize the distribution of anti-dsDNA antibodies in the lesions of kidney, but also semi-quantify the deposition of these antibodies, which are the key cause of the local damage. To sum up, this study provides a simple approach for rational design of nanoscale SLE-targeting nanomedicine to improve the diagnose and treatment of SLE, also sheds light on the possible mechanisms of anti-dsDNA antibodies in the pathogenesis and progression of SLE.
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