蝗虫
斑马鱼
药物代谢
质谱法
药品
质谱成像
化学
药理学
生物
计算生物学
色谱法
生物化学
生态学
基因
作者
Marvin Villacrez,Karin Hellman,Tatsuya Ono,Y. Sugita,Melinda Rezeli,Fredrik Ek,György Markó-Varga,Roger Olsson
标识
DOI:10.1021/acschemneuro.7b00459
摘要
Studying how and where drugs are metabolized in the brain is challenging. In an entire organism, peripheral metabolism produces many of the same metabolites as those in the brain, and many of these metabolites can cross the blood-brain barrier from the periphery, thus making the relative contributions of hepatic and brain metabolism difficult to study in vivo. In addition, drugs and metabolites contained in ventricles and in the residual blood of capillaries in the brain may overestimate drugs' and metabolites' concentrations in the brain. In this study, we examine locusts and zebrafish using matrix assisted laser desorption ionization mass spectrometry imaging to study brain metabolism and distribution. These animal models are cost-effective and ethically sound for initial drug development studies.
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