炎症体
急性胰腺炎
医学
胰腺炎
发病机制
炎症
荟萃分析
动物研究
内科学
药理学
免疫学
作者
Lin Gao,Eric Chong,Sayali A. Pendharkar,Jiwon Hong,John A. Windsor,Lu Ke,Anthony R.J. Phillips
出处
期刊:Pancreas
[Ovid Technologies (Wolters Kluwer)]
日期:2022-01-01
卷期号:51 (1): 13-24
被引量:6
标识
DOI:10.1097/mpa.0000000000001971
摘要
Acute pancreatitis (AP) is an inflammatory disease, and NLRP3 inflammasome activation is involved in the pathogenesis of AP. Previous research showed that inhibition of NLRP3 inflammasome may exert protective effects on animal models of AP and reduces disease severity. The aim of this systematic review and meta-analysis is to evaluate the effects of drug treatment of NLRP3 inflammasome on the outcomes of experimental AP. PubMed, Embase, Medline, and Web of Science databases were searched for relevant articles without language restrictions. The main outcomes for this study included local pancreatic injury, the incidence of systemic inflammatory responses, and the incidence of organ failure. Twenty-eight animal studies including 556 animals with AP were included in the meta-analysis. Compared with controls, inhibition of NLRP3 inflammasome significantly reduced the pancreatic histopathological scores, serum amylase, and lipase levels. In addition, inhibition of NLRP3 inflammasome reduced the levels of circulating inflammatory cytokines, as well as mitigating severity of AP-associated acute lung injury and acute intestinal injury. To conclude, inhibition of NLRP3 inflammasome has protective effects on AP by mitigating organ injury and systemic inflammation in animal studies, indicating that NLRP3 inflammasome holds promise as a target for specific AP therapy.
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