Outside Back Cover: Ligand‐Mediated Reprogramming Redirects Liver‐Tropic Ionizable Lipid Nanoparticles for Lung‐Selective mRNA Delivery (Angew. Chem. Int. Ed. 38/2026)

In Research Article e6080664, Lulu Xue and co-workers present a ligand-mediated lipid reprogramming strategy that redirects liver-tropic ionizable lipids toward lung-selective mRNA delivery. Site-specific installation of small-molecule ligands onto the headgroup of the 2-t6b ionizable lipid enables precise organ retargeting while preserving the parent scaffold, resulting in markedly enhanced efficacy for lung-targeted mRNA delivery and genome editing applications.