Visible Light‐Induced Aerobic Oxidative −H Arylation of Glycine Derivatives

Abstract A direct aerobic oxidative dehydrogenative coupling reaction of glycine derivatives with electron‐rich arenes has been accomplished via the synergistic combination of organic‐dye mediated photoredox catalysis and Lewis acid catalysis. This process exhibits good tolerance of functional groups and provides rapid synthesis of arylglycine derivatives at room temperature under an air atmosphere. Moreover, this protocol could be performed on a 10 mmol scale, without obvious reduction of the yield. magnified image