材料科学
生物相容性
生物医学工程
期限(时间)
纳米技术
系统工程
工程类
医学
量子力学
物理
冶金
作者
Jun Li,Kang Liu,Yanhao Yu,Yin Long,Justin J. Jeffery,Weibo Cai,Xudong Wang
出处
期刊:Nano Energy
[Elsevier]
日期:2018-09-01
卷期号:51: 728-735
被引量:69
标识
DOI:10.1016/j.nanoen.2018.07.008
摘要
Implantable nanogenerator (i-NG) has shown great promises for enabling self-powered implantable medical devices (IMDs). One essential requirement for practical i-NG applications is its long-term bio-compatibility and bio-safety. This paper presents a systematic study of polydimethylsiloxane (PDMS) and PDMS/Parylene-C packaged polyvinylidene fluoride (PVDF) NGs implanted inside female ICR (Institute of Cancer Research) mice for up to six months. The PVDF NG had a stable in vitro output of 0.3 V when bended for 7200 cycles and an in vivo output of 0.1 V under stretching. Multiple advanced imaging techniques, including computed tomography (CT), ultrasound, and photoacoustic were used to characterize the embedded i-NGs in vivo. The i-NGs kept excellent adhesion to the adjacent muscle surface, and exhibited stable electrical output during the entire examine period. No signs of toxicity or incompatibility were observed from the surrounding tissues, as well as from the whole body functions by pathological analyses and blood and serum test. The PDMS package was also able to effectively insulate the i-NG in biological environment with negligible stray currents at a pA scale. This series of in-vivo and in-vitro studies confirmed the biological feasibility of using i-NG in vivo for biomechanical energy harvesting.
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