自噬
骨质疏松症
糖皮质激素
成骨细胞
发病机制
医学
平衡
骨形成
细胞生物学
内分泌学
内科学
生物
生物化学
细胞凋亡
体外
作者
Lufei Wang,Bradlee L. Heckmann,Xianrui Yang,Hu Long
摘要
Administration of glucocorticoids is an effective strategy for treating many inflammatory and autoimmune diseases. However, glucocorticoid treatment can have adverse effects on bone, leading to glucocorticoid-induced osteoporosis (GIO), the most common form of secondary osteoporosis. Although the pathogenesis of GIO has been studied for decades, over the past ten years the autophagy machinery has been implicated as a novel mechanism. Autophagy in osteoblasts, osteocytes, and osteoclasts plays a critical role in the maintenance of bone homeostasis. Herein, we specifically discuss how osteoblast autophagy responds to glucocorticoids and its role in the development of GIO.
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