药物化学
基础(拓扑)
联轴节(管道)
有机化学
小学(天文学)
高分子化学
作者
Prosenjit Daw,Amit Kumar,Noel Angel Espinosa-Jalapa,Yehoshoa Ben-David,David Milstein
摘要
Amide synthesis is one of the most important transformations in chemistry and biology. The direct use of ammonia for the incorporation of nitrogen functionalities in organic molecules is an attractive and environmentally benign method. We present here a new synthesis of amides by acceptorless dehydrogenative coupling of benzyl alcohols and ammonia. The reaction is catalyzed by a pincer complex of earth-abundant manganese in the presence of a stoichiometric base, making the overall process economical, efficient, and sustainable. Interesting mechanistic insights based on detailed experimental observations, indicating the crucial role of the base, are provided.
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