神经毒性
锰
氧化锰
化学
纳米颗粒
螯合作用
氧化应激
生物物理学
毒性
无机化学
生物化学
纳米技术
材料科学
生物
有机化学
作者
Aniruddha Adhikari,Mousumi Das,Susmita Mondal,Soumendra Darbar,Anjan Kumar Das,Siddhartha Bhattacharya,Debasish Pal,Samir Kumar Pal
出处
期刊:Biomaterials Science
[The Royal Society of Chemistry]
日期:2019-01-01
卷期号:7 (11): 4491-4502
被引量:17
摘要
Here, we have compared the behavioral neurotoxicity of a manganese nanoformulation (citrate functionalized Mn3O4 nanoparticles; C-Mn3O4 NPs) with that of the well-known neurotoxicant, ionic Mn, in an animal model. We found that mice administered with C-Mn3O4 NPs showed no signs of a neurobehavioral disorder, but the NPs instead ameliorated Mn-induced neurotoxicity (Parkinson's-like syndrome) through the chelation of excess Mn ions and subsequent reduction of oxidative damage.
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