医学
间充质干细胞
肌成纤维细胞
纤维化
伤口愈合
癌症研究
免疫学
病理
作者
Darryl A. Knight,Christopher Grainge,Stephen M. Stick,Anthony Kicic,Michael Schuliga
出处
期刊:Chest
[Elsevier]
日期:2020-06-01
卷期号:157 (6): 1591-1596
被引量:19
标识
DOI:10.1016/j.chest.2019.12.014
摘要
Aberrant wound repair and fibrosis play a fundamental role in many major diseases concerning pulmonologists, including all forms of pulmonary fibrosis as well as COPD, asthma, cystic fibrosis (CF), bronchiolitis obliterans syndrome (BOS), and bronchiectasis. Accordingly, understanding normal and abnormal wound repair in the lung is a major objective of many academic groups and industry programs; one aspect of wound repair requiring urgent attention focuses on what drives the increased number of extracellular matrix (ECM)-secreting mesenchymal cells.
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