肝母细胞瘤
基因型
优势比
单倍型
医学
肿瘤科
内科学
荟萃分析
胃肠病学
生物
遗传学
基因
作者
Huitong Chen,Yong Li,Li Li,Jinhong Zhu,Zhonghua Yang,Jiao Zhang,Suhong Li,Yijuan Xin,Hongmei Xia,Jing He
摘要
Abstract Background Hepatoblastoma is a commonly occurring embryonal tumors in children. N6‐methyladenosine (m 6 A) plays a critical role in gene expression, thus contributing to the occurrence and progression of cancer. RNA splicing is regulated by the nuclear m 6 A reader YTHDC1 , yet the roles of YTHDC1 polymorphisms in hepatoblastoma remain unclear. Methods We conducted a seven‐center case–control study to determine the association between YTHDC1 gene polymorphisms (rs2293596 T>C, rs2293595 T>C and rs3813832 T>C) and hepatoblastoma susceptibility. We recruited 313 hepatoblastoma patients and 1446 healthy controls. Results There was no significant association between all of these polymorphisms and hepatoblastoma susceptibility in single locus or combined analysis. Stratification analysis revealed that rs2293596 TC/CC genotype carriers had a higher risk of developing hepatoblastoma in the subgroup of clinical stages III + IV [adjusted odds ratio (OR) = 1.80, 95% confidence interval (CI) = 1.18–2.76, p = 0.007]. In addition, 3 risk genotype carriers are more likely to develop hepatoblastoma in the subgroup of clinical stages III + IV (adjusted OR = 1.80, 95% CI = 1.18–2.76, p = 0.007). Furthermore, false‐positive probability analysis was used to notarize our findings. Haplotype analysis indicated that there was no significant association between inferred haplotypes of YTHDC1 gene based on observed genotypes and hepatoblastoma risk. Conclusions In conclusion, our findings suggest that the rs2293596 T>C polymorphism may contribute to hepatoblastoma susceptibly and YTHDC1 gene polymorphisms may have a cumulative effect on hepatoblastoma risk.
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