盒内非相干运动
医学
核医学
磁共振成像
曼惠特尼U检验
灌注
接收机工作特性
感兴趣区域
动态增强MRI
相关性
磁共振弥散成像
有效扩散系数
放射科
内科学
数学
几何学
作者
Hongyan Wang,Lixia Zhu,Guohua Li,M N Zuo,Xiaolu Ma,Jianliang Wang
标识
DOI:10.1177/0284185119890086
摘要
Intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) is a functional magnetic resonance imaging (MRI) sequence.To evaluate the value of perfusion parameters derived from IVIM-DWI based on tumor edge region of interest (ROI) in differentiation in cervical cancer and investigate the relationship between IVIM and dynamic contrast-enhanced MRI (DCE-MRI).Thirty-three patients with pathologically diagnosed squamous cell carcinoma who underwent IVIM-DWI (nine b-values: 1-1000 s/mm2) and DCE-MRI were retrospectively assessed in this study. Parameters of IVIM (D, f, D*, fD*) and quantitative parameters of DCE-MRI (Ktrans, Kep, Ve) were derived using tumor edge ROI. Mann-Whitney U test was used to compare parameters between pathological grades and receiver operating characteristic (ROC) curves were used. Pearson's correlation coefficient (r) evaluated the correlation between perfusion parameters derived from IVIM and DCE-MRI.The poorly differentiated group showed the significantly lower D value and the higher f, Ktrans and Kep values than the well-to-moderately differentiated group (P < 0.05). ROC curves indicated that f < 26%, Ktrans <0.38/min, and Kep <1.62/min could differentiate the poorly differentiated group from the well-to-moderately differentiated group (AUC 0.753-0.808). Significantly positive correlations were found between f and Ktrans (r = 0.422, P = 0.014) and between fD* and Ktrans (r = 0.448, P = 0.009).Perfusion parameters derived from IVIM based on tumor edge ROI may offer additional value in differentiation in cervical cancer, and the IVIM perfusion parameters showed moderate positive correlations with quantitative perfusion parameters from DCE-MRI, while f and fD* showed promising significance.
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