生物
Wnt信号通路
运行x2
细胞生物学
整合素
信号转导
连环蛋白
转录因子
遗传学
细胞
基因
作者
Xiaoshan Wu,Jinrong Hu,Guoqing Li,Yan Li,Li Yang,Jing Zhang,Fu Wang,Ang Li,Lei Hu,Zhipeng Fan,Shouqin Lü,Gang Ding,Chunmei Zhang,Jinsong Wang,Mian Long,Songlin Wang
标识
DOI:10.15252/embj.2019102374
摘要
Renewal of integumentary organs occurs cyclically throughout an organism's lifetime, but the mechanism that initiates each cycle remains largely unknown. In a miniature pig model of tooth development that resembles tooth development in humans, the permanent tooth did not begin transitioning from the resting to the initiation stage until the deciduous tooth began to erupt. This eruption released the accumulated mechanical stress inside the mandible. Mechanical stress prevented permanent tooth development by regulating expression and activity of the integrin β1-ERK1-RUNX2 axis in the surrounding mesenchyme. We observed similar molecular expression patterns in human tooth germs. Importantly, the release of biomechanical stress induced downregulation of RUNX2-wingless/integrated (Wnt) signaling in the mesenchyme between the deciduous and permanent tooth and upregulation of Wnt signaling in the epithelium of the permanent tooth, triggering initiation of its development. Consequently, our findings identified biomechanical stress-associated Wnt modulation as a critical initiator of organ renewal, possibly shedding light on the mechanisms of integumentary organ regeneration.
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