磷酰胆碱
材料科学
聚合物
甲基丙烯酸酯
蛋白质吸附
部分
纳米医学
膜
纳米技术
高分子化学
化学
纳米颗粒
聚合
有机化学
复合材料
生物化学
作者
Tatsuro Goda,Kazuhíko Ishihara,Yuji Miyahara
摘要
ABSTRACT 2‐Methacryloyloxyethyl phosphorylcholine (MPC) is a custom methacrylate with a zwitterionic phosphorylcholine moiety on the side chain. In the past 25 years, MPC has been used as a building block for a wide range of polymeric biomaterials because of its excellent resistance to nonspecific protein adsorption, cell adhesion, and blood coagulation. Recently, MPC polymers with specific features have been used in bioengineering and nanomedicine. This review focuses on three topics that highlight the latest findings on MPC polymers, that is, specific recognition of C‐reactive protein (CRP), cell‐membrane‐penetration abilities, and lubrication properties. These developments will extend the applications of this biomimetic material from bioinert polymers to biosensing, CRP inhibitors, prodrug carriers, subcellular bioimaging, cell manipulation, and joint replacement. © 2015 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2015 , 132 , 41766.
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