化学
抗氧化剂
根茎
一氧化氮
活性氧
DPPH
一氧化氮合酶
蒸馏水
生物化学
消炎药
激进的
传统医学
肿瘤坏死因子α
药理学
生物
免疫学
色谱法
有机化学
医学
作者
Trishna Debnath,Sa Ra Park,Da Hey Kim,Jeong Eun Jo,Beong Ou Lim
出处
期刊:Asian Pacific Journal of Tropical Disease
[Asian Pacific Journal of Tropical Medicine Press]
日期:2013-08-01
卷期号:3 (4): 308-313
被引量:33
标识
DOI:10.1016/s2222-1808(13)60074-2
摘要
To investigate the antioxidant and anti-inflammatory activities of distilled water extract of fresh Polygonatum sibiricum (P. sibiricum) rhizome. The extracts were tested for antioxidant activity by using DPPH (1,1-diphenyl-2-picryl-hydrazyl), and hydroxyl (OH•) radicals scavenging activity. The level of intracellular reactive oxygen species (ROS) was determined in H2O2 treated chang liver cells. Anti-inflammatory activity was evaluated by the inhibition of nitric oxide (NO), inducible nitric oxide synthase (iNOS), as well as tumor necrosis factor-alpha (TNF-α) protein expression in a lipopolysaccharide stimulated Raw 264.7 murine macrophages cell line. P. sibiricum water extracts scavenged DPPH, OH• radicals and decreased the level ROS. The extracts reduced NO reduction and inhibited the expression of iNOS and TNF-α proteins. The findings indicate that water extracts of P. sibiricum could be considered as natural antioxidants and anti-inflammatory agents for food and drug industries.
科研通智能强力驱动
Strongly Powered by AbleSci AI