肠道菌群
失调
肠-脑轴
疾病
快速眼动睡眠行为障碍
微生物群
一级亲属
丁酸盐
医学
帕金森病
生物
免疫学
生物信息学
内科学
家族史
发酵
食品科学
作者
Bei Huang,Steven Wai Ho Chau,Yaping Liu,Joey Wing Yan Chan,Jing Wang,Shang‐keng Ma,Jihui Zhang,Paul K.S. Chan,Yun Kit Yeoh,Zigui Chen,Li Zhou,Sunny H. Wong,Vincent Mok,Ka‐Fai To,H. M. Lai,Simon Ng,Claudia Trenkwalder,Francis K.L. Chan,Yun Kwok Wing
标识
DOI:10.1038/s41467-023-38248-4
摘要
The microbiota-gut-brain axis has been suggested to play an important role in Parkinson's disease (PD). Here we performed a cross-sectional study to profile gut microbiota across early PD, REM sleep behavior disorder (RBD), first-degree relatives of RBD (RBD-FDR), and healthy controls, which could reflect the gut-brain staging model of PD. We show gut microbiota compositions are significantly altered in early PD and RBD compared with control and RBD-FDR. Depletion of butyrate-producing bacteria and enrichment of pro-inflammatory Collinsella have already emerged in RBD and RBD-FDR after controlling potential confounders including antidepressants, osmotic laxatives, and bowel movement frequency. Random forest modelling identifies 12 microbial markers that are effective to distinguish RBD from control. These findings suggest that PD-like gut dysbiosis occurs at the prodromal stages of PD when RBD develops and starts to emerge in the younger RBD-FDR subjects. The study will have etiological and diagnostic implications.
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