Organocatalytic oxa‐Michael/Michael Addition/Deformylation Cascade Reaction of 3‐Formylchromone with p‐Quinol: Synthesis of the Furanochromanone Skeleton

Abstract An approach for the construction of furanochromanone skeletons has been developed through a DABCO‐catalyzed cascade reaction with good yields (up to 83%) and high diastereoselectivity (>20:1 dr). Notably, the asymmetric catalytic version of this reaction was further studied, obtaining furanochromanones bearing four contiguous stereogenic centers with excellent enantio‐ and diastereoselectivity (up to 98% ee, >20:1 dr). This protocol causes the formation of a variety of substituted furanochromanones via an oxa‐Michael/Michael addition/deformylation cascade reaction. magnified image