Bioinspired nanomedicines for the management of osteosarcoma: Recent progress and perspectives

Osteosarcoma (OS) is the most prevalent malignant primary bone tumor, predominantly affecting children and young adults between the ages of 11 and 20. OS presents huge challenges in treatment because of its aggressive nature and high metastatic potential. Chemotherapeutic drugs have attracted considerable interest for the treatment of OS, but they suffer from poor targeting, low bioavailability, severe side effects, and the multi-drug resistance acquired by the tumor. Therefore, it is imperative to develop novel therapeutic tactics that can improve OS outcomes while minimizing toxicity. Bioinspired nanoparticles, designed through exploiting or simulating the biological structures and processes, provide promising strategies for the treatment of OS. In this review, we elaborate on the biological properties and biomedical applications of state-of-the-art bioinspired nanoparticles, including cell membrane-based nanoparticles, exosome-based nanoparticles, protein template-based nanoparticles, and peptide template-based nanoparticles for the management of OS.