病理
粘液
生物
转录组
杯状细胞
免疫学
肺
免疫组织化学
基础（医学）
医学
上皮
基因表达
基因
内科学
生态学
生物化学
胰岛素
内分泌学
作者
Stephen A. Schworer,Hiroki Murano,Hong Dang,Matthew R. Markovetz,Minako Saito,Takafumi Kato,Takanori Asakura,Gang Chen,Rodney C. Gilmore,L. Morton,Catharina van Heusden,Michael Chua,E.R. Strickler,Z. Wiśniewski,Gillian Crisp,Edwin A. Mitchell,Kayleigh A. Doherty,Shania Mastan,Humberto E. Trejo Bittar,B. Cody
标识
DOI：10.1164/rccm.202409-1849oc
摘要
Asthmatic bronchioles exhibit a T2-driven proximalization associated with mucus plugging. MUC5AC-high niches were identified heterogeneously in bronchiolar epithelia independent of immune cell localizations, suggesting asthmatic bronchioles contain cellular niches which perpetuate T2-initiated epithelial remodeling.
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