Design, Synthesis, and Biological Evaluation of Pyrazol‐5‐yl‐quinoline‐2‐carboxamide Derivatives as Potential Fungicidal Agents

Fungal infections in agricultural crops can lead to significant reductions in both yield and quality. To identify more potential fungicides, pyrazol-5-yl-quinoline-2-carboxamide derivatives were designed, synthesized, and evaluated for their fungicidal activities. The bioassay results indicated that compound C-10 exhibited lower EC50 values of 1.71 and 4.92 mg/L against Gaeumannomyces graminis and Valsa mali compared to fluxapyroxad (EC50 = 1.93 and 12.45 mg/L, respectively). The results of the molecular docking and SDH enzymatic inhibition assays could explain the potential action mechanism of compound C-10. This study provides support for the development of pyrazol-5-yl-quinoline-2-carboxamide derivatives as potential fungicides.