病毒学
猴痘
牛痘
病毒
生物
正痘病毒
核糖核酸
痘病毒科
基因
重组DNA
生物化学
作者
Jinge Zhou,Tong Ye,Yun Yang,Entao Li,Kaiyue Zhang,Yuping Wang,Shaohong Chen,Junbo Hu,Kai Zhang,Fang Liu,Rui Gong,Xia Chuai,Zefeng Wang,Sandra Chiu
标识
DOI:10.1016/j.ymthe.2024.04.028
摘要
Since the outbreak of mpox in 2022, widespread concern has been placed on imposing an urgent demand for specific vaccines that offer safer and more effective protection. Using an efficient and scalable circular RNA (circRNA) platform, we constructed four circRNA vaccines that could induce robust neutralizing antibodies as well as T-cell responses by expressing different surface proteins of monkeypox virus (MPXV), resulting in potent protection against vaccinia virus (VACV) in mice. Strikingly, the combination of the four circular RNA vaccines demonstrated the best protection against VACV challenge among all the tested vaccines. Our study provides a favorable approach for developing MPXV-specific vaccines by using a circular mRNA platform and opens up novel avenues for future vaccine research.
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