加合物
菊粉
化学
立体化学
有机化学
医学
替代医学
病理
中医药
作者
Cong Guo,Ruo-Yu Qi,Jun Ren,Dandan Xu,Qiang Zhang,Jin‐Ming Gao,Jiang‐Jiang Tang
标识
DOI:10.1021/acs.joc.4c00248
摘要
Inubritantrimer A (1), a trace trimerized sesquiterpenoid [4 + 2] adduct featuring an unusual exo-exo type spiro-polycyclic scaffold, together with three new endo-exo [4 + 2] adducts, inubritantrimers B–D (2–4), were discovered from the flowers of Inula britannica. Their structures were elucidated using 1D/2D NMR, X-ray diffraction, and ECD approaches. 1 is characterized as a novel exo-exo trimer, synthesized biogenetically from three sesquiterpenoid monomers, featuring a unique linkage of C-11/C-1′, C-13/C-3′ and C-13′/C-3″, C-11′/C-1″ through a two-step exo [4 + 2] cycloaddition process. Compounds 1–4 exhibited modest cytotoxicity against breast cancer cells with IC50 values in the range of 5.84–12.01 μM.
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