半桥粒
细胞生物学
基底膜
表皮(动物学)
再生(生物学)
细胞外基质
干细胞
生物
角质形成细胞
整合素
皮肤表皮交界处
电池极性
皮肤当量
细胞分化
细胞
解剖
细胞培养
真皮
生物化学
遗传学
基因
作者
Patricia Rousselle,Chloé Laigle,Gaelle Rousselet
出处
期刊:American Journal of Physiology-cell Physiology
[American Physiological Society]
日期:2022-12-01
卷期号:323 (6): C1807-C1822
被引量:4
标识
DOI:10.1152/ajpcell.00069.2022
摘要
The epidermis is a specialized epithelium that constitutes the outermost layer of the skin, and it provides a protective barrier against environmental assaults. Primarily consisting of multilayered keratinocytes, the epidermis is continuously renewed by proliferation of stem cells and the differentiation of their progeny, which undergo terminal differentiation as they leave the basal layer and move upward toward the surface, where they die and slough off. Basal keratinocytes rest on a basement membrane at the dermal-epidermal junction that is composed of specific extracellular matrix proteins organized into interactive and mechanically supportive networks. Firm attachment of basal keratinocytes, and their dynamic regulation via focal adhesions and hemidesmosomes, is essential for maintaining major skin processes, such as self-renewal, barrier function, and resistance to physical and chemical stresses. The adhesive integrin receptors expressed by epidermal cells serve structural, signaling, and mechanosensory roles that are critical for epidermal cell anchorage and tissue homeostasis. More specifically, the basement membrane components play key roles in preserving the stem cell pool, and establishing cell polarity cues enabling asymmetric cell divisions, which result in the transition from a proliferative basal cell layer to suprabasal cells committed to terminal differentiation. Finally, through a well-regulated sequence of synthesis and remodeling, the components of the dermal-epidermal junction play an essential role in regeneration of the epidermis during skin healing. Here too, they provide biological and mechanical signals that are essential to the restoration of barrier function.
科研通智能强力驱动
Strongly Powered by AbleSci AI