医学
美罗华
硫唑嘌呤
霉酚酸酯
强的松
血管炎
中枢神经系统
环磷酰胺
维持疗法
疾病
重症监护医学
内科学
移植
化疗
淋巴瘤
标识
DOI:10.1016/j.nic.2023.07.008
摘要
Primary central nervous system vasculitis (PCNSV) is a vasculitis limited to the brain and spinal cord. Induction therapy often consists of steroids and cyclophosphamide. Maintenance therapy includes a prednisone taper and may be combined with medications such as azathioprine or mycophenolate mofetil. Relapse is common in PCNSV and an increased dose of steroids is often given, sometimes with a change in therapy. Medications such as rituximab and mycophenolate mofetil may be good alternatives in those who do not respond to initial treatment or who have relapse of disease. Mortality rates of 8% to 9% are reported in the literature.
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