化学
胺化
吲哚
催化作用
组合化学
立体化学
有机化学
作者
Jun Tang,Fengjie Lu,Yi Sun,Guodong Zhang,Ensheng Zhang,Yuan‐Ye Jiang
标识
DOI:10.1021/acs.joc.3c01897
摘要
Site-selective C–H fluorination is an attractive strategy for directly transforming inert C–H bonds into C–F bonds, yet it remains a significant challenge. Herein, we have developed an efficient and versatile strategy for site-selective fluorination and amination of phenylalanine-containing peptides via late-stage Pd-catalyzed δ-C(sp2)-H activation, providing a valuable tool for the in situ synthesis of fluorinated indoline scaffolds within peptides.
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