期刊:Science [American Association for the Advancement of Science (AAAS)] 日期:2015-02-12卷期号:347 (6223): 732-732
标识
DOI:10.1126/science.347.6223.732-f
摘要
Humoral Immunity
To successfully fight a pathogen, immunological B cells must wage a multipronged attack: They can differentiate into antibody-secreting plasma cells or become T cell–helping germinal center cells, or even long-lived memory cells. But can a single B cell acquire all of these different fates? To find out, Taylor et al. tracked the responses of single B cells in mice. Although some B cells acquired only one fate, others differentiated into all three. The authors linked the ability of B cells to differentiate into multiple subsets to their ability to proliferate and resist cell death, and the affinity of their antigen receptor.
Science , this issue p. [784][1]
[1]: /lookup/doi/10.1126/science.aaa1342