Poloxamer 407-induced hyperlipidemia animal model in Kunming mice

【Objective】 Hyperlipidemia is a well-established risk factor for cardiovascular morbidity.We attempted to develop a chemically-induced hyperlipidemic animal model in Kunming mice,using poloxamer 407.【Methods】 Male Kunming mice were randomly divided into 2 groups:control group without any intervention and poloxamer 407 group.After fasted overnight,a bolus of poloxamer 407(0.3 g/kg) was intraperitoneally injected into mice,and blood triglyceride and cholesterol were measured at 0,3,6,24,48 and 72 h after the injection.【Results】 Poloxamer 407 caused the increase of blood triglyceride more than 40-fold and cholesterol 5-fold.And this hyperlipidemic effect of poloxamer 407 lasted up to 72 h after injection.【Conclusions】 Poloxamer 407 induced Kunming mice may be used as a new hyperlipidemic animal model.