Oncolytic herpes simplex virus and its advances in cancer therapy

Oncolytic virotherapy represents an emerging modality with tremendous promise for cancer treatment. Among various oncolytic virues,oncolytic herpes simplex virus is one of the most widely explored agents and shows significant anti tumor activity.In this review,we mainly discuss the advantages of oncolytic HSV,the principles of HSV genetic manipulation,the strategies of oncolytic HSV development and targeting,the ad- vances and challenges of oncolytic HSV in cancer therapy.