[Purpose] To explore the influence of ultrasonography and mammography based on the women's age and breast cancer tumor size in breast cancer screening and diagnosis.[Methods] All patients were examined by ultrasonography and mammography in the same day.The lesion location,size and imaging features were recorded.Diagnosis was made independently by senior physician of ultrasound and radiography professional in the double blind manner.[Results] In 1 132 lesions of 1 090 cases,314 breast cancer lesions of 301 cases and 818 benign foci of 789 cases were confirmed by pathology.The sensitivity,specificity,false negative rate were 95.22%,65.16%,4.78% for ultrasonography and 90.13%,86.31%,9.87% for mammography,respectively.The differences between the ultrasonography and mammography were statistically significant(P 0.05).The sensitivity and specificity were 97.77% and 92.42% for joint ultrasonography and mammography.Mammography had a lower sensitivity than ultrasonography in women younger than 50 years,whereas the sensitivity of ultrasonography was similar to mammography in women older than 50 years.The sensitivity in the mass 6~10mm group was lowest for mammography that had significant difference compared with ultrasonography(P0.05).[Conclusions] The sensitivity of ultrasonography is greater than that of mammography in women younger than 50 years in breast cancer examination.Ultrasonography has a similar effect with mammography in women older than 50 years.The sensitivity was lowest for mammography in patients with the mass 6~10mm.