Objective To study the application of spraying granulation technique in Leonurus Granules Through experiments.Methods Spraying granulation method was employed to optimize the preparation process of Leonurus Granules,and compared with the original Wet granulation method.Results Spraying granulation process method prepared the particles with the appropriate hardness and stable quality,reduced the amount of materials.Conclusion Spraying granulation technique for the preparation of Leonurus Granules can effectively improve the production efficiency,reduce production costs,that was suitable for industrial mass production.