异构化
化学
二异丙基氨基锂
烯丙基重排
双环分子
有机化学
锂(药物)
微波辐射
溶剂
烷基
光化学
催化作用
离子
医学
脱质子化
内分泌学
作者
Gabriella Barozzino‐Consiglio,Alessandro Mordini
出处
期刊:Letters in Organic Chemistry
[Bentham Science]
日期:2018-04-12
卷期号:15 (5): 447-454
标识
DOI:10.2174/1570178615666180215145359
摘要
The present work reports a study on the isomerization reactions of several alkyl epoxides to the corresponding allylic alcohols or bicyclic alcohols under microwave irradiation. The reaction occurred in the presence of lithium diisopropylamide as a base and different experimental conditions in terms of solvent, amount of the base, times and temperatures. The traditional heating with an oil-bath and the use of alternative organometallic bases, as the Lochmann-Schlosser bases, have been furthermore compared with the microwave heating. The results obtained show that the use of microwave irradiations on promoting the isomerization of epoxides gives access to a series of synthetically useful products, among which allylic alcohols and bicyclic alcohols, depending on the starting substrate. Keywords: Microwave irradiation, epoxides, allylic alcohols, isomerization reactions, lithium diisopropylamide, superbases.
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