生物
细胞生物学
细胞周期
MAPK/ERK通路
激酶
蛋白激酶A
丝裂原活化蛋白激酶
细胞周期蛋白依赖激酶2
信号转导
细胞周期蛋白
细胞周期蛋白依赖激酶4
抗凋亡Ras信号级联
丝裂原活化蛋白激酶3
细胞生长
丝裂原活化蛋白激酶激酶
ASK1
MAP激酶激酶激酶
细胞
生物化学
作者
Sylvain Meloche,Jacques Pouysségur
出处
期刊:Oncogene
[Springer Nature]
日期:2007-05-14
卷期号:26 (22): 3227-3239
被引量:983
标识
DOI:10.1038/sj.onc.1210414
摘要
The Ras-dependent extracellular signal-regulated kinase (ERK)1/2 mitogen-activated protein (MAP) kinase pathway plays a central role in cell proliferation control. In normal cells, sustained activation of ERK1/ERK2 is necessary for G1- to S-phase progression and is associated with induction of positive regulators of the cell cycle and inactivation of antiproliferative genes. In cells expressing activated Ras or Raf mutants, hyperactivation of the ERK1/2 pathway elicits cell cycle arrest by inducing the accumulation of cyclin-dependent kinase inhibitors. In this review, we discuss the mechanisms by which activated ERK1/ERK2 regulate growth and cell cycle progression of mammalian somatic cells. We also highlight the findings obtained from gene disruption studies.
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