化学
三乙胺
雷尼镍业
产量(工程)
吡啶
废止
碘甲烷
碘化物
立体专一性
氯化物
药物化学
有机化学
内酰胺
催化作用
冶金
材料科学
作者
Shweta Sharma,U. Mehra,Prabhat K. Gupta
出处
期刊:Tetrahedron
[Elsevier]
日期:1980-01-01
卷期号:36 (23): 3427-3429
被引量:13
标识
DOI:10.1016/0040-4020(80)80195-5
摘要
Amides 1 on reaction with P2S5 in pyridine give thioamides 2 which on treatment with methyl iodide afford the corresponding 1-methylthio-3,4-dihydroisoquinolines 3. Annelation of these imines with phenoxyacetyl chloride in the presence of triethylamine furnish 6-methylthio-7-phenoxy-2',3' - dimethoxybenzo[a]octem 4a and 6-methylthio-7-phenoxy-2,3-methylenedioxybenzo[a]octem 4b respectively. Desulphurisation of these β-methylthio-β-lactams with Raney nickel yield the novel polycyclic cis-β-lactams 5a and 5b.
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