生物
成纤维细胞生长因子受体
信号
成纤维细胞生长因子
平衡
细胞生物学
信号转导
受体
信号通路
神经科学
遗传学
作者
Edward Carter,Abbie E. Fearon,Richard Grose
标识
DOI:10.1016/j.tcb.2014.11.003
摘要
Since its discovery 40 years ago, fibroblast growth factor (FGF) receptor (FGFR) signalling has been found to regulate fundamental cellular behaviours in a wide range of cell types. FGFRs regulate development, homeostasis, and repair and are implicated in many disorders and diseases; and indeed, there is extensive potential for severe consequences, be they developmental, homeostatic, or oncogenic, should FGF-FGFR signalling go awry, so careful control of the pathway is critically important. In this review, we discuss the recent developments in the FGF field, highlighting how FGFR signalling works in normal cells, how it can go wrong, how frequently it is compromised, and how it is being targeted therapeutically.
科研通智能强力驱动
Strongly Powered by AbleSci AI