化学
部分
可见光谱
催化作用
光化学
光催化
组合化学
有机化学
光催化
光电子学
物理
作者
Jaehun Jung,Eun Jin Kim,Youngmin You,Eun Jin Cho
标识
DOI:10.1002/adsc.201400542
摘要
Abstract Difluoroalkylated aromatics are important structural motifs in pharmaceutical and agrochemical applications. Herein, we report their synthesis by a mild, efficient, and convenient method using visible light photoredox catalysis. A variety of unactivated aromatics were difluoroalkylated with ethyl 2‐bromo‐2,2‐difluoroacetate (BrCF 2 CO 2 Et) in the presence of the triscyclometalated Ir complex fac ‐[Ir(ppy) 3 ] under visible light irradiation at room temperature. It is shown that reaction outcomes containing the CF 2 CO 2 Et moiety can be converted to a variety of other CF 2 ‐containing aromatics, demonstrating the synthetic utility of the present method. magnified image
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