共价键
生物化学
酶
残留物(化学)
化学
体内
共价结合
结构生物学
糖苷水解酶
体外
计算生物学
组合化学
生物
有机化学
生物技术
作者
Brian P. Rempel,Stephen G. Withers
出处
期刊:Glycobiology
[Oxford University Press]
日期:2008-08-01
卷期号:18 (8): 570-586
被引量:156
标识
DOI:10.1093/glycob/cwn041
摘要
Glycoside hydrolases are important enzymes in a number of essential biological processes. Irreversible inhibitors of this class of enzyme have attracted interest as probes of both structure and function. In this review we discuss some of the compounds used to covalently modify glycosidases, their use in residue identification, structural and mechanistic investigations, and finally their applications, both in vitro and in vivo, to complex biological systems.
科研通智能强力驱动
Strongly Powered by AbleSci AI